Purigen Biosystems, Inc.

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Purigen Simplifies Simultaneous Extraction and Purification of DNA and RNA from Challenging FFPE Samples

Company is showcasing advantages of the automated Ionic® Complete FFPE Purification Kit during the virtual AGBT 2021 meeting

Pleasanton, Calif. – March 2, 2021Purigen Biosystems, Inc., a leading provider of next-generation technologies for extracting and purifying nucleic acids from biological samples, today announced the launch of the Ionic® FFPE Complete Purification Kit. Scientists are now able to consistently recover both DNA and RNA (mRNA and miRNA) simultaneously from formalin-fixed, paraffin-embedded (FFPE) tissue samples in a single workflow. Purigen is showcasing the advantages of the new kit during the virtual Advances in Genome Biology and Technology (AGBT) 2021 annual meeting.

Purigen’s dedicated FFPE to Pure DNA and FFPE to Pure RNA Kits enable scientists to purify and concentrate superior yields of DNA or RNA from precious samples, and the new Ionic FFPE Complete Purification Kit rounds out Purigen’s FFPE purification portfolio. With this addition, Purigen enables users of the Ionic system to simultaneously extract and purify high yields of DNA and RNA from the same FFPE section or scroll — all while using a streamlined workflow that reduces hands-on time by as much as 75% in comparison to manual column or bead-based methods. The combination of a simple workflow with a simultaneous extraction of DNA and RNA at high yield and quality enables researchers to maximize rare or precious FFPE samples.

“Our customers inquire about purifying RNA and DNA from the same FFPE specimens to perform downstream assays,” says Ajay Pandita, CSO at Canopy Biosciences, a Bruker Company. “With the Ionic FFPE Complete Purification Kit, we can simultaneously extract RNA and DNA with less than half of the hands-on time that other methods require.” Having recently completed the beta testing of the FFPE Complete Purification Kit, Pandita also noted that his team found the absence of tedious steps to be a clear advantage over the traditional methods.

The Ionic FFPE Complete Purification Kit utilizes Purigen’s Ionic® Purification System, a compact benchtop instrument that enables the automated extraction of pure and abundant nucleic acids from a wide range of sample types, including cultured or sorted cells and FFPE tissue. These biological samples are gently lysed and loaded into an Ionic® Fluidic Chip. The Ionic System uses the company’s innovative isotachophoresis (ITP) technology to apply an electric field to the chip, which isolates the nucleic acids in their natural, native form. Since the nucleic acids are not denatured or dehydrated, nor are they bound and stripped from fixed surfaces, the process minimizes fragmentation and eliminates any bead or buffer contamination. The prepared nucleic acids are ready for analysis by downstream techniques such as next-generation sequencing (NGS) or qPCR.

“The FFPE Complete Purification kit takes the advantages of our first kits for FFPE samples a step further by providing a simple workflow to simultaneously purify both RNA and DNA from the same sample,” said Barney Saunders, PhD, CEO of Purigen Biosystems. “Scientists can now access high yields of high-quality DNA and RNA while conserving precious sample and saving time.”

The Ionic FFPE Complete Purification Kit consists of 12 chips and a reagent set with all necessary enzymes and buffers to perform DNA extraction from 48 samples. The kit is available now through Purigen’s direct sales channels. For more information, please visit: www.purigen.co/ffpecomplete.

Advances in Genome Biology and Technology (AGBT) 2021 General Meeting
Purigen is exhibiting and showcasing its Ionic Purification System during the virtual AGBT General Meeting on March 1-3, 2021. For more information on the company’s AGBT activities, please visit www.purigen.co/agbt2021.

About Purigen Biosystems
Purigen Biosystems is redefining nucleic acid sample preparation with an innovative platform based on the highly efficient isotachophoresis technology invented by Juan Santiago, PhD, and his team at Stanford University. Purigen’s automated benchtop instrumentation and accompanying microfluidic chip purify nucleic acid samples from a wide variety of sources, including minute or otherwise challenging cancer samples. The purified nucleic acids are then immediately compatible with a wide range of downstream detection methods, including next-generation sequencing, PCR, and other genomic tests. For more information, visit www.purigenbio.com.

Ionic is a registered trademark of Purigen Biosystems, Inc. All other trademarks are the property of their respective owners. All products described herein are intended FOR RESEARCH USE ONLY and NOT FOR USE IN DIAGNOSTIC PROCEDURES.


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