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Purigen Biosystems, Inc.

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  • A New Future Together

    Purigen Biosystems is Now Part of Bionano Genomics

    Together we will continue advancing isotachophoresis (ITP) on the Ionic® Purification System throughout genomics and, as part of Bionano, further simplify and accelerate DNA isolation for optical genome mapping.

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  • Releasing, revealing and accessing insights
    locked in biological specimens

    The Next-Gen Sample Prep System

    The revolutionary Ionic® Purification System requires no binding, no stripping, and no washing from fixed surfaces for much higher yields and higher quality nucleic acid.

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  • No Beads, No Columns, No Surface-binding

    Simple, Automated, Charge-based DNA and RNA Extraction

    Isotachophoresis separates and concentrates charged molecules in solution solely based on their electrophoretic mobility for pure DNA, RNA, and miRNA extraction.

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  • Ionic® Tissue to Pure DNA

    Improved Yields from Fresh Frozen Tissue

    Simple, automated extraction of DNA from a variety of tissue types with less hands-on time than conventional bead- and column-based methods.

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  • Proof-of-Performance (POP) Program

    Test Your Samples on the Ionic® System

    We invite you try our Ionic system and see the difference. Our POP program is available to any researcher wanting to compare their traditional methods / results to the Ionic® Purification System.

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Pure, Native, Intact DNA, RNA and miRNA
Biological samples are gently lysed without the use of chaotropic salts. Nucleic acids are not denatured or dehydrated.
Higher Amplifiable Yields and Better Data
Extract up to 50% more DNA from cultured cells, and 3.5x more DNA and 2x more RNA from FFPE samples versus traditional column-based methods.
No Beads, No Columns,
No Surface-binding
Nucleic acids are purified solely based on electrophoretic mobility. Elimination of binding, washing, and stripping reduces sample loss and contamination.
No Risk Downstream
Purification is not biased toward nucleic acids of a certain length or GC content.
Superior Workflow for FFPE
Extraction of RNA, DNA, and miRNA from FFPE scrolls or slides requires less than
3 minutes of hands-on time per sample (lysis included). No chemical deparaffinization is required.
Automated Nucleic Acid Purification
Nucleic acids are automatically separated and concentrated from sample lysate on the Ionic Purification System in
~60 minutes.

See the Ionic Purification System in Action

The application of ITP to purify and quantify nucleic acids from complex biological samples was pioneered by Purigen co-founder and Stanford University Professor, Juan G. Santiago. The Ionic Purification System is compatible with a range of samples including cells and FFPE to help researchers, scientists, pathologists, and oncologists find the best method for DNA and RNA extraction.

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Purigen's FFPE to Pure DNA and RNA Automated Workflow

Total hands-on time is ~24 minutes per 8 samples

Purigen FFPE Workflow
Purigen Ionic System – FFPE to DNA/RNA Workflow   MORE INFO